Registration Dossier

Administrative data

Endpoint:
pH
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27-09-2017 – 27-09-2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard OECD test guidelines

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report Date:
2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 122 (Determination of pH, Acidity and Alkalinity)
Principles of method if other than guideline:
The pH determination of test item trans-menthone (CAS No. 89-80-5) was done as per the test guideline OECD 122, with the help of digital pH meter.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- IUPAC Name: (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one- Common Name: Menthone/ trans-menthone- InChI: 1S/C10H18O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-9H,4-6H2,1-3H3- Smiles:C1([C@@H](CC[C@@H](C1)C)C (C)C)=O- Molecular formula:C10H18O - Molecular weight :154.2512 g/mole- Substance type: Organic- Physical state: Clear liquid (colourless to yellowish)- Purity: 98% (by GC)
Specific details on test material used for the study:
- IUPAC Name: (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one- Common Name: Menthone/ trans-menthone- InChI: 1S/C10H18O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-9H,4-6H2,1-3H3- Smiles:C1([C@@H](CC[C@@H](C1)C)C (C)C)=O- Molecular formula:C10H18O - Molecular weight :154.2512 g/mole- Substance type: Organic- Physical state: Clear liquid (colourless to yellowish)- Purity: 98% (by GC)

Reagents

Reagent:
water

Results and discussion

pH value
Key result
pH value:
3.78
Temp.:
26.5 °C
Remarks on result:
other: 1% w/v emulsion of the test item

Any other information on results incl. tables

TEST DESCRIPTION AND RESULT

Method Details

Observations

Remarks if, any

Guideline

OECD 122

 

 

Method

Digital pH meter

 

Principle of Method

The mean pH of an aqueous solution or dispersion in water was determined with a pH measurement interface equipped with an appropriate electrode system.

 

Temperature of 1% w/v test emulsion

 

26.5°C

mean pH (RESULT)

 

3.78

Inference

 

1.  Acidic

2.  Basic

3.  Neutral

 

 

Acidic

Applicant's summary and conclusion

Conclusions:
The pH of 1% w/v emulsion of the test item trans-menthone (CAS No 89-80-5) was 3.78 at 26.5 °C.
Executive summary:

The pH determination of test item trans-menthone (CAS No 89-80-5) was done following OECD guideline 122. pH of 1% w/v emulsion was measured with the help of pH meter and it was observed to be 3.78 at 26.5 °C.