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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer- reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Acute oral toxicity study of test chemical was performed in rodents.
Author:
D. L. J. Opdyke
Year:
1976
Bibliographic source:
Food and Cosmetics Toxicology
Reference Type:
secondary source
Title:
Acute oral toxicity study of test chemical was performed in rodents.
Author:
Food and Drug Administration
Year:
1985
Bibliographic source:
National Technical Information Service

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute oral toxicity of (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no.: 89-80-5) in rats
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- IUPAC Name: (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one- Common Name: Menthone- InChI: 1S/C10H18O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-9H,4-6H2,1-3H3- Smiles:C1([C@@H](CC[C@@H](C1)C)C (C)C)=O- Molecular formula:C10H18O - Molecular weight :154.2512 g/mole- Substance type:Organic
Specific details on test material used for the study:
- IUPAC Name: (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one- Common Name: Menthone- InChI: 1S/C10H18O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-9H,4-6H2,1-3H3- Smiles:C1([C@@H](CC[C@@H](C1)C)C (C)C)=O- Molecular formula:C10H18O - Molecular weight :154.2512 g/mole- Substance type: Organic- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
not specified
Doses:
Range of 1820-2620 mg/kg bw
No. of animals per sex per dose:
groups of 10 M and 10 F
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 950 mg/kg bw
Based on:
test mat.
95% CL:
1 820 - 2 620
Remarks on result:
other: 50% mortality observed
Mortality:
50% mortality observed at 1950 mg/kg bw.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 was considered to be 1950 mg/kg bw, with 95% confidence limit of 1820-2620 mg/kg bw, when rats were treated with (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no.: 89-80-5) via oral gavage route.
Executive summary:

The acute oral toxicity study was conducted by using (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no.: 89-80-5) in groups of 10 male and 10 female rats at the dose concentration range between 1820-2620 mg/kg bw.50% mortality observed at1950 mg/kg bw. Therefore, LD50 was considered to be 1950 mg/kg bw, with 95% confidence limit of 1820-2620 mg/kg bw, when rats were treated with (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no.: 89-80-5) via oral gavage route.