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EC number: 201-941-1 | CAS number: 89-80-5
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
The second order hydrolysis rate constant of test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one was determined to be in range 0.01- 0.030 L/mol-sec . The half life of hydrolysis of test chemical was estimated was in range of 2.0 - 7.3 years at pH 7 and 78 - 270 days at pH 8 . These range half life of hydrolysis was indicates that test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one is not hydrolysable.
Additional information
Hydrolysis:
Half life of Hydrolysis of test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no. 89-80-5) was estimated by applying weight of evidence approach using experimental data from structurally and functionally similar read across chemicals. The studies are as mentioned below:
The first experimental study was reviewed from authoritative database (HSDB) in this study the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant was determined to be 0.03L/mol-sec with corresponding half-lives of 7.3 yrs and 270 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the chemical is not hydrolysable.
Next experimental study was also reviewed from same authoritative database mentioned above in this study the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical . The second order hydrolysis rate constant was determined to be 0.01L/mol-sec with corresponding half-lives of 2 yrs and 78 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the chemical is not hydrolysable.
By considering results of both the studies mentioned above it can be concluded that test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no. 89-80-5)is not hydrolysable.
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