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Hydrolysis:

The second order hydrolysis rate constant of test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one was determined to be  in range 0.01- 0.030 L/mol-sec . The half life of hydrolysis  of test chemical was estimated was in range of  2.0 - 7.3 years  at pH 7 and  78 - 270 days at pH 8 . These range half life of hydrolysis was indicates that test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one is not hydrolysable.

Additional information

Hydrolysis:

Half life of Hydrolysis of test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no. 89-80-5) was estimated by applying weight of evidence approach using experimental data from structurally and functionally similar read across chemicals. The studies are as mentioned below:

The first experimental study was reviewed from authoritative database (HSDB) in this study the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant was determined to be 0.03L/mol-sec with corresponding half-lives of 7.3 yrs and 270 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the chemical is not hydrolysable.

Next experimental study was also reviewed from same authoritative database mentioned above in this study the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical . The second order hydrolysis rate constant was determined to be 0.01L/mol-sec with corresponding half-lives of 2 yrs and 78 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the chemical is not hydrolysable.

By considering results of both the studies mentioned above it can be concluded that test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no. 89-80-5)is not hydrolysable.