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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Data is from experimental studies of read across chemicals
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Related information:
Composition 1
Reason / purpose:
read-across source
Related information:
Composition 1
Reference:
Composition 0
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Determination of base catalyzed second order hydrolysis rate constant and half-life of test chemical
GLP compliance:
not specified
Test material information:
Composition 1
Radiolabelling:
not specified
Analytical monitoring:
not specified
Estimation method (if used):
Structure estimation method
Transformation products:
not specified
pH:
7
Half-life:
7.3 yr
Type:
second order
Remarks on result:
other: Hydrolysis rate constant is 0.03 L/mol-sec.
pH:
8
Half-life:
270 d
Type:
second order
Remarks on result:
other: Hydrolysis rate constant is 0.03 L/mol-sec.
pH:
7
Half-life:
2 yr
Type:
second order
Remarks on result:
other: Hydrolysis rate constant is 0.01L/mol-sec
pH:
8
Half-life:
78 d
Type:
second order
Remarks on result:
other: Hydrolysis rate constant is 0.01L/mol-sec
Validity criteria fulfilled:
not specified
Conclusions:
The second order hydrolysis rate constant of test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one was determined to be in range 0.01- 0.030 L/mol-sec . The half life of hydrolysis of test chemical was estimated was in range of 2.0 - 7.3 years at pH 7 and 78 - 270 days at pH 8 . These range half life of hydrolysis was indicates that test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one is not hydrolysable.
Executive summary:

Half life of Hydrolysis of test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no. 89-80-5) was estimated by applying weight of evidence approach using experimental data from structurally and functionally similar read across chemicals. The studies are as mentioned below:

The first experimental study was reviewed from authoritative database (HSDB)in this study the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant was determined to be 0.03L/mol-sec with corresponding half-lives of 7.3 yrs and 270 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the chemical is not hydrolysable.

Next experimental study was also reviewed from same authoritative database mentioned above in this study the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical . The second order hydrolysis rate constant was determined to be 0.01L/mol-sec with corresponding half-lives of 2 yrs and 78 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the chemical is not hydrolysable.

By considering results of both the studies mentioned above it can be concluded that test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no. 89-80-5)is not hydrolysable.

Description of key information

The second order hydrolysis rate constant of test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one was determined to be  in range 0.01- 0.030 L/mol-sec . The half life of hydrolysis  of test chemical was estimated was in range of  2.0 - 7.3 years  at pH 7 and  78 - 270 days at pH 8 . These range half life of hydrolysis was indicates that test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one is not hydrolysable.

Key value for chemical safety assessment

Additional information

Half life of Hydrolysis of test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no. 89-80-5) was estimated by applying weight of evidence approach using experimental data from structurally and functionally similar read across chemicals. The studies are as mentioned below:

The first experimental study was reviewed from authoritative database (HSDB)in this study the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant was determined to be 0.03L/mol-sec with corresponding half-lives of 7.3 yrs and 270 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the chemical is not hydrolysable.

Next experimental study was also reviewed from same authoritative database mentioned above in this study the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical . The second order hydrolysis rate constant was determined to be 0.01L/mol-sec with corresponding half-lives of 2 yrs and 78 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the chemical is not hydrolysable.

By considering results of both the studies mentioned above it can be concluded that test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no. 89-80-5)is not hydrolysable.