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EC number: 212-112-9
CAS number: 763-69-9
Groups of 15 male and 15 female rats were exposed to target vapor
concentrations of 1000, 500, 250, or 0 ppm ethyl 3-ethoxypropionate
(EEP) 6h/day, 5 days/week, and received 65-67 exposures over 13 weeks.
Effects related to exposure were lethargy during exposure to 1000 ppm,
decreased body weight gain and clinical signs of irritation such as
sialorrhea and lacrimation at 1000 and 500 ppm. Differences in
hematology, clinical chemistry, terminal body and organ weight values
were seen, but the effects were small, the severity of the effects were
slight and they appeared to be secondary to the weight gain depression.
The effects seen with EEP were of a non-specific nature. One female
exposed to 1000 ppm died on Day 54 of the study. No cause of death was
The no-observed effect level for toxicity is 250 ppm EEP and the
no-observed adverse effect level is 500 ppm with the principal change
being weight gain depression following exposure to 500 and 1000 ppm EEP
for 13 weeks.
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