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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Non-GLP study equivalent to OECD guidelines 404 and 405 are available for ethyl 3-ethoxypropionate. 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Skin: application of ethyl 3 -ethoxypropionate to rabbit skin resulted only in very slight effects in 1 out of 6 animals. All effects were fully reversible within 2 days.


Eye: in a study of acceptable quality (Klimisch 2) no eye irritation was observed any of the 6 animals (all scores were 0 after 24, 48 and 72 hours). In an older study (from 1946) with a Klimisch rating 4 (not assignable) 0.5 ml caused serious necrosis in the rabbit eye, while 0.1 ml caused only slight injury placing the compound in our grade 3 for eye injury. However, this study is not considered to be of acceptable quality as only insufficient details are provided in the study report and no data is available regarding impurities that might have influenced the irritation study.

Justification for classification or non-classification

Skin irritation: according to EEC Council Directive 67/548/EEC (amended by Directive 83/467/EEC) the mean value of the scores for erythema and for edema was 0.1. According to annex VI of the directive ethyl 3-ethoxypropionate is not classified as skin irritant.

Eye irritation: according to the annex VI of the council directive 67/548 EEC (amended by directive 83/467 EEC) the average scores for cornea, iris, conjunctivae and chemosis were 0 after 24, 48 and 72 hours for all animals. According to EEC criteria no labelling for eye irritancy is required.