Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

A GLP-study according to OECD guideline 401 and several non-GLP studies equivalent or similar to OECD guidelines 401, 402 and 403 are available for ethyl 3-ethoxypropionate.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
4 309 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
5 967 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
4 080 mg/kg bw

Additional information

Oral: several studies on acute oral toxicity in rats are available for ethyl 3 -ethoxypropionate (EEP). All studies are of acceptable quality (Klimisch rating 1 or 2) and the reported LD50 values are all greater than 3200 mg/kg bw. The lowest LD50 of 4309 reported in the key study for female rats is taken forward for the risk assessment.


 


Dermal: several studies on acute dermal toxicity in rabbits and guinea pigs are available for ethyl 3 -ethoxypropionate. All studies are of acceptable quality (Klimisch 2) and the lowest reported LD50 was 4080 mg/kg bw in male rabbits. In guinea pigs no deaths were observed up to the highest dose tested (20 ml/kg bw).


 


Inhalation: several studies on acute inhalation toxicity in rats are available for ethyl 3 -ethoxypropionate. All studies are acceptable with restrictions (Klimisch 2). No mortality was observed in any of the studies at substantially saturated vapor concentrations. The highest concentration (998 ppm, 5967 mg/m3) that has been verified with analytics is taken forward for the risk assessment.

Justification for classification or non-classification

LD50 values for oral and dermal route are greater than 2000 mg/kg/bw and no mortality was observed in any of the acute inhalation studies at substantially saturated vapor concentrations. According to the EU criteria for classification and labeling, ethyl 3 -ethoxypropionate is not classified for acute toxicity for any route of exposure.