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Diss Factsheets
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EC number: 212-112-9 | CAS number: 763-69-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A GLP-study according to OECD guideline 401 and several non-GLP studies equivalent or similar to OECD guidelines 401, 402 and 403 are available for ethyl 3-ethoxypropionate.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 4 309 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 5 967 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 4 080 mg/kg bw
Additional information
Oral: several studies on acute oral toxicity in rats are available for ethyl 3 -ethoxypropionate (EEP). All studies are of acceptable quality (Klimisch rating 1 or 2) and the reported LD50 values are all greater than 3200 mg/kg bw. The lowest LD50 of 4309 reported in the key study for female rats is taken forward for the risk assessment.
Dermal: several studies on acute dermal toxicity in rabbits and guinea pigs are available for ethyl 3 -ethoxypropionate. All studies are of acceptable quality (Klimisch 2) and the lowest reported LD50 was 4080 mg/kg bw in male rabbits. In guinea pigs no deaths were observed up to the highest dose tested (20 ml/kg bw).
Inhalation: several studies on acute inhalation toxicity in rats are available for ethyl 3 -ethoxypropionate. All studies are acceptable with restrictions (Klimisch 2). No mortality was observed in any of the studies at substantially saturated vapor concentrations. The highest concentration (998 ppm, 5967 mg/m3) that has been verified with analytics is taken forward for the risk assessment.
Justification for classification or non-classification
LD50 values for oral and dermal route are greater than 2000 mg/kg/bw and no mortality was observed in any of the acute inhalation studies at substantially saturated vapor concentrations. According to the EU criteria for classification and labeling, ethyl 3 -ethoxypropionate is not classified for acute toxicity for any route of exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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