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EC number: 212-112-9 | CAS number: 763-69-9
A GLP-study according to OECD guideline 401 and several non-GLP studies equivalent or similar to OECD guidelines 401, 402 and 403 are available for ethyl 3-ethoxypropionate.
Oral: several studies on acute oral toxicity in rats are available for ethyl 3 -ethoxypropionate (EEP). All studies are off acceptable quality (Klimisch rating 1 or 2) and the reported LD50 values are all greater than 3200 mg/kg bw. The lowest LD50 of 4309 reported in the key study for female rats is taken forward for the risk assessment.
Dermal: several studies on acute dermal toxicity in rabbits and guinea pigs are available for ethyl 3 -ethoxypropionate. All studies are of acceptable quality (Klimisch 2) and the lowest reported LD50 was 4080 mg/kg bw in male rabbits. In guinea pigs no deaths were observed up to the highest dose tested (20 ml/kg bw).
Inhalation: several studies on acute inhalation toxicity in rats are available for ethyl 3 -ethoxypropionate. All studies are acceptable with restrictions (Klimisch 2). No mortality was observed in any of the studies at substantially saturated vapor concentrations. The highest concentration (998 ppm, 5967 mg/m3) that has been verified with analytics is taken forward for the risk assessment.
LD50 values for oral and dermal route are greater than 2000 mg/kg/bw and no mortality was observed in any of the acute inhalation studies at substantially saturated vapor concentrations. According to the EU criteria for classification and labeling, ethyl 3 -ethoxypropionate is not classified for acute toxicity for any route of exposure.
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