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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Acute dermal toxicity study in Rabbit for CAS no: 4394-85-8
Author:
GESTIS SUBSTANCE DATABASE
Year:
2017
Bibliographic source:
Institute for occupational safety and health of the German social accident insurance.2017

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity study of morpholine-4-carbaldehyde was performed in Rabbit.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):morpholine-4-carbaldehyde
- Molecular formula :C5H9NO2
- Molecular weight :115.131g/mole
- Substance type:organic
- Physical state:solid
- Purity:No data available
- Impurities (identity and concentrations):No data available
Specific details on test material used for the study:
- Name of test material (as cited in study report):morpholine-4-carbaldehyde
- Molecular formula :C5H9NO2
- Molecular weight :115.131g/mole
- Substance type:organic
- Physical state:solid
- Purity:No data available
- Impurities (identity and concentrations):No data available

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
18300mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 18 300 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No Mortality was observed
Mortality:
No mortality was observed
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be >18300mg/kg body weight. When rabbits were treated with morpholine-4-carbaldehyde (4394-85-4) by dermal application.
Executive summary:

Acute dermal toxicity study was done in rabbit using morpholine-4-carbaldehyde (4394-85-4).No mortality was observed at dose 18300mg/kg bw .Hence LD50 was considered to be >18300mg/kg body weight on dermal application