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EC number: 230-053-7 | CAS number: 6928-85-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute dermal toxicity study in Rabbit for CAS no: 4394-85-8
- Author:
- GESTIS SUBSTANCE DATABASE
- Year:
- 2 017
- Bibliographic source:
- Institute for occupational safety and health of the German social accident insurance.2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of morpholine-4-carbaldehyde was performed in Rabbit.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
Test material
- Reference substance name:
- morpholine-4-carbaldehyde
- Cas Number:
- 4394-85-8
- Molecular formula:
- C5H9NO2
- IUPAC Name:
- morpholine-4-carbaldehyde
- Details on test material:
- - Name of test material (as cited in study report):morpholine-4-carbaldehyde
- Molecular formula :C5H9NO2
- Molecular weight :115.131g/mole
- Substance type:organic
- Physical state:solid
- Purity:No data available
- Impurities (identity and concentrations):No data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):morpholine-4-carbaldehyde
- Molecular formula :C5H9NO2
- Molecular weight :115.131g/mole
- Substance type:organic
- Physical state:solid
- Purity:No data available
- Impurities (identity and concentrations):No data available
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 18300mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 18 300 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No Mortality was observed
- Mortality:
- No mortality was observed
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be >18300mg/kg body weight. When rabbits were treated with morpholine-4-carbaldehyde (4394-85-4) by dermal application.
- Executive summary:
Acute dermal toxicity study was done in rabbit using morpholine-4-carbaldehyde (4394-85-4).No mortality was observed at dose 18300mg/kg bw .Hence LD50 was considered to be >18300mg/kg body weight on dermal application
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