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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA.
Qualifier:
according to
Guideline:
other: modelling database
Principles of method if other than guideline:
Prediction done using ECOSAR v.1.11 model.
GLP compliance:
no
Specific details on test material used for the study:
- Name of test material (as cited in study report): 4-Methylpiperazin-1-amine
- Molecular formula: C5H13N3
- Molecular weight: 115.179 g/mol
- Substance type: organic
- Physical state: Liquid
- Smiles notation: N1(CCN(CC1)C)N
- InChl: 1S/C5H13N3/c1-7-2-4-8(6)5-3-7/h2-6H2,1H3
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: Fish
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
165 000 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: not toxic
Conclusions:
On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to Fish was predicted to be 165000 mg/l for 4-methylpiperazin-1-amine in 96 hrs. Based on the LC50 value, it can be concluded that the substance 4-methylpiperazin-1-amine can be considered as not toxic to aquatic environment and thus classified in “not classified” as per the CLP criteria.
Executive summary:

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to Fish was predicted to be 165000 mg/l for 4-methylpiperazin-1-amine in 96 hrs. Based on the LC50 value, it can be concluded that the substance 4-methylpiperazin-1-amine can be considered as not toxic to aquatic environment and thus classified in “not classified” as per the CLP criteria.

Description of key information

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to Fish was predicted to be 165000 mg/l for 4-methylpiperazin-1-amine in 96 hrs. Based on the LC50 value, it can be concluded that the substance 4-methylpiperazin-1-amine can be considered as not toxic to aquatic environment and thus classified in “not classified” as per the CLP criteria.

Key value for chemical safety assessment

LC50 for freshwater fish:
165 000 mg/L

Additional information

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to Fish was predicted to be 165000 mg/l for 4-methylpiperazin-1-amine in 96 hrs. Based on the LC50 value, it can be concluded that the substance 4-methylpiperazin-1-amine can be considered as not toxic to aquatic environment and thus classified in “not classified” as per the CLP criteria.