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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Acute oral toxicity study in Rat for CAS no: 5632-47-3
Author:
U.S .National library of medicine
Year:
2017
Bibliographic source:
ChemID plus A TOXNET DATABASE.2017

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of 1Nitrosopiperazine was performed in Rat
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):1Nitrosopiperazine
- Molecular formula :C4H9N3O
- Molecular weight :115.135g/mole
- Substance type:organic
- Physical state:No data available
- Purity:No data available
- Impurities (identity and concentrations):No data available
Specific details on test material used for the study:
- Name of test material (as cited in study report):1Nitrosopiperazine
- Molecular formula :C4H9N3O
- Molecular weight :115.135g/mole
- Substance type:organic
- Physical state:No data available
- Purity:No data available
- Impurities (identity and concentrations):No data available

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
2260mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 260 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed
Clinical signs:
brain and coverings "changes in circulation like hemorrhage, thrombosis, etc.in liver: fatty liver degeration and in lungs, thorax, or respiration acute
pulmonary edema were observed in treated rats.
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not Classified
Conclusions:
LD50 was considered to be2260mg/kgbody weight. When rats were treated with1Nitrosopiperazine(5632-47-3) orally.
Executive summary:

Acute oral toxicity study was done in rat using1Nitrosopiperazine(5632-47-3) by oral route. 50% mortality was observed at dose 5560mg/kg bw. Clinical signs like brain and coverings "changes in circulation(hemorrhage, thrombosis, etc.)",in liver fatty liver degeration and in lungs, thorax, or respiration acute pulmonary edema were observed in treated rats. Hence LD50 was considered to be 2260mg/kg body weight. When rats were treated with1Nitrosopiperazine(5632-47-3) orally.