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Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Short-term toxicity to fish

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to Fish was predicted to be 165000 mg/l for 4-methylpiperazin-1-amine in 96 hrs. Based on the LC50 value, it can be concluded that the substance 4-methylpiperazin-1-amine can be considered as not toxic to aquatic environment and thus classified in “not classified” as per the CLP criteria.

Short-term toxicity to aquatic invertebrates

Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic invertebrates was predicted for 4-methylpiperazin-1-amine (Cas no. 6928-85-4). Effect concentration i.e EC50 value was estimated to be 163.39 mg/l for Daphnia magna for 48 hrs duration. It was concluded that the 4-methylpiperazin-1-amine (Cas no. 6928-85-4) was likely to be not-toxic to aquatic invertebrates, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.

Toxicity to aquatic algae and cyanobacteria

Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, the toxicity on algae was predicted for 4-methylpiperazin-1-amine (Cas no. 6928-85-4). Effect concentration i.e EC50 value was estimated to be 108.59 mg/l for Pseudokirchneriella subcapitata for 96 hrs duration. It was concluded that the 4-methylpiperazin-1-amine (Cas no. 6928-85-4) was likely to be not-toxic to aquatic algae, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.

Additional information

Short-term toxicity to fish

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to Fish was predicted to be 165000 mg/l for 4-methylpiperazin-1-amine in 96 hrs. Based on the LC50 value, it can be concluded that the substance 4-methylpiperazin-1-amine can be considered as not toxic to aquatic environment and thus classified in “not classified” as per the CLP criteria.

Short-term toxicity to aquatic invertebrates

Four studies including predicted data from validated tools and experimental data from peer reviewed journal for toxicity to aquatic invertebrate endpoint of test chemical 4-methylpiperazin-1-amine (Cas no. 6928-85-4) with relevant read across which is close to target using log Kow as primary descriptor were summarised as follows:

 

Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic invertebrates was predicted for 4-methylpiperazin-1-amine (Cas no. 6928-85-4). Effect concentration i.e EC50 value was estimated to be 163.39 mg/l for Daphnia magna for 48 hrs duration. It was concluded that the 4-methylpiperazin-1-amine (Cas no. 6928-85-4) was likely to be not-toxic to aquatic invertebrates, hence it can be considered to benot classifiedas per the CLP classification criteria for aquatic environment.

 

Similar prediction done by Using the EPI Suite ECOSAR version 1.11, the LC50 value for short term toxicity to aquatic invertebrate was predicted to be 406.90 mg/l for 4-methylpiperazin-1-amine in 48 hrs. Based on the LC50 value, it can be concluded that the substance 4-methylpiperazin-1-amine is not toxic.

 

Above predicted results for target is assisted by experimental data of read across chemicalN,N-dimethylformamide(Cas no. 68-12-2) from handbook,The Lethal concentration to 50% (LC50) of Crangon crangon is 100 mg/l at 48 h. On the basis of the value it can be concluded that the N,N-dimethylformamide is not toxic to the aquatic environment.

 

Another experimental data of read acrossN,N-dimethylformamide (Cas no. 68-12-2) from Archives of Environmental Contamination and Toxicology 1983 indicates that the lethal concentration LC50 for daphnia magna at 48 hrs is 12350 mg/l. It can be concluded that the N,N-dimethylformamide is not toxic to aquatic environment.

Thus based on the effect concentrations which is in the range100mg/l to12350give the conclusion that test substance 4-methylpiperazin-1-amine (Cas no. 6928-85-4) was likely to be non-toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered to benot classifiedas per the CLP classification criteria.

 

Toxicity to aquatic algae and cyanobacteria

Four studies including predicted data from validated tools and experimental data from peer reviewed journal for toxicity to aquatic algae endpoint of test chemical 4-methylpiperazin-1-amine (Cas no. 6928-85-4) with relevant read across which is close to target using log Kow as primary descriptor were

summarised as follows:

 

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primarydescriptor and considering the six closest read across substances, the toxicity on algae was predicted for 4-methylpiperazin-1-amine (Cas no. 6928-85-4). Effect concentration i.e EC50 value was estimated to be 108.59 mg/l for Pseudokirchneriella subcapitata for 96 hrs duration.

 

Similar prediction by EPI suite, ECOSAR version 1.1, On the basis of EPI suite, ECOSAR version 1.1, the EC50 value for toxicity to aquatic algae was predicted to be 12583.529 mg/l for 4-methylpiperazin-1-amine in 96 hrs.

 

Above predicted results for target is assisted by experimental data of read across chemicalMetformin(Cas no. 657-24-9) from Toxicology Letters 2003,indicates that the Effective concentration to 50% of Desmodesmus subspicatus at which decrease in population growth rate was measured is 320 mg/L.

Another experimental data of read acrossN,N-dimethylformamide (Cas no. 68-12-2) from Bulletin of Environmental Contamination and Toxicology 1983 indicates that NOEC value for Selenastrum capricornutum in 14 days is 470 mg/l.

Thus based on the effect concentrations which is in the range 108.59 mg/l to 12583.529 mg/Lgive the conclusion that test substanceSulphoacetic acid(Cas no.123-43-1) was likely to be non-toxic to aquatic algae at environmentally relevant concentrations and can be considered to be not classified as per the CLP classification criteria.