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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
100 mg/L

Additional information


The acute toxicity of .beta.-Cyclodextrin (100.6% pure) to Daphnia magna was assessed in a static 48-hour Immobilization test according to OECD Guideline 202. The study encompassed two treatment groups (one test item concentration at nominal 100 mg/L and one control) each containing 20 individuals. The immobility of the daphnia was determined in a static 48-hour test by visual controls after 24 and 48 hours. The samples of the test medium were analysed via TOC-method at test start and after 48 hours of test duration showing a recovery of 84 - 87 %. Therefore, all reported biological results are related to the nominal concentrations of the test item. After 48 hours of exposure one immobile daphnia was observed in the control and the test item concentration of 100 mg/L. According to the test guidelines this immobilization rate is tolerated in the control and therefore is not seen as a toxic effect in the 100 mg/L test concentration. All validity criteria were met. In the most recent test with the reference item potassium dichromate the EC50 after 24 hours was determined to be 2.0 mg test item/L indicating that the sensitivity of the Daphnia was consistent with the level proposed by the OECD 202 guideline (EC50-24 h between 0.5 and 2.1 mg potassium dichromate/L). The 48-hour NOEC was >=100 mg test item/L, the EC50 was > 100 mg/L.