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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Report with some details lacking

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Groups of 10 animals per sex were dosed subcutaneous with 1000 mg/kg body weight. The animals were pobserved for 14 days.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cycloheptapentylose
EC Number:
231-493-2
EC Name:
Cycloheptapentylose
Cas Number:
7585-39-9
Molecular formula:
C42H70O35
IUPAC Name:
5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.2~3,6~.2~8,11~.2~13,16~.2~18,21~.2~23,26~.2~28,31~]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol (non-preferred name)
Details on test material:
beta-cyclodextrin was used

Test animals

Species:
rat
Strain:
other: CFY
Sex:
male/female
Details on test animals or test system and environmental conditions:
animals had a weight of 150 - 200 g, no other data available

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
water
Details on exposure:
no data available
Doses:
1000 mg/kg body weight.
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
LD50 according to Litchfiled Wilcoxson

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
> 1 000 mg/kg bw
Remarks on result:
other: none
Sex:
female
Dose descriptor:
LD50
Effect level:
> 1 000 mg/kg bw
Remarks on result:
other: none
Mortality:
Male: 0/10 males administered with 1000 mg/kg bw died during the course of this test.
Female: 0/10 females administered with 1000 mg/kg bw died during the course of this test.
Clinical signs:
Clinical signs were erethism and tonicity as well as hyperpnoea beginning 7 minutes post adminisitration
Body weight:
not observed
Gross pathology:
not reported
Other findings:
not reported

Applicant's summary and conclusion

Conclusions:
The LD50 of beta-cyclodextrin administered to rats subcutaneously was > 1000 mg/kg bw for females and males.