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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

Under the conditions of the present test .beta.-Cyclodextrin induced no lethal effects in carp at or below 4500 mg/l, the LC50 was 7561 mg/l.

Key value for chemical safety assessment

LC50 for freshwater fish:
7 561 mg/L

Additional information

A 96-Hour Acute Toxicity study in Carp was performed with .beta.-Cyclodextrin. The study procedures were based on the OECD guideline No. 203, Adopted 17 July, 1992. Initially, a limit test was performed with carp exposed to 100 mg/l in a

static system. No visible effects occurred during the 96-hour test period. Hence, the 96h-LC50 for carp exposed to .beta.-Cyclodextrin was >100 mg/l. An additional limit test was performed with seven carp exposed to a concentration of 10,000 mg/l. Six out of seven carp exposed died within 24 hours of exposure. Hence, a second final test was performed with seven carp exposed to concentrations ranging from 1000 to 10,000 mg/l in a static system to determine the LC50. The 96-hour LC50 was already reached after 24 hours of exposure. The LC50 was 7561 mg/l, the NOEC was 4500 mg/l.