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EC number: 208-358-1
CAS number: 524-38-9
No skin sensitization reaction was observed
according to the study. 12 controls showed negative reactions to the
dilution 10- 3 (w/w).
Patch test was conducted for 2-hydroxy-1H-isoindole-1,3(2H)-dione
(524-38-9) on human .A 2-hydroxy-1H-isoindole-1,3(2H)-dione atdilution
of (0.00001)10-5 w/w and (0.000001)10-6 (w/w) in ethanol were applied by
using patch on to the skin of an old man. He showedpositive
reaction at 0.00001 concentration in ethanol but negative at 0.000001
concentration in ethanol during induction exposure. After
a rest period of 4 months. At
challenge ,test material at
thedilution of (0.001)10-3 and (0.0001)10-4(w/w) in ethanol
were applied by using patch on to the skin of same person., He showedpositive
in ethanol but negative at(0.0001)10-4concentration
in ethanol during challenge.
Therefore, the substance 2-hydroxy-1H-isoindole-1,3(2H)-dione
(524-38-9)was considered to be not sensitizing to human by
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