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Description of key information

Bioaccumulation: aquatic / sediment

From BCFBAF Program (v3.00) model of EPI suite and PBT profiler the estimated bio concentration factor (BCF) for 2-hydroxy-1H-isoindole-1,3(2H)-dione is 3.2 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that 2-hydroxy-1H-isoindole-1,3(2H)-dione is not expected to bio accumulate in the aquatic environment.

Additional information

Bioaccumulation: aquatic / sediment

Four studies including all predicted data from validated models and experimental data from authorative database for bioaccumulation (BCF) endpoint of target chemical 2-hydroxy-1H-isoindole-1,3(2H)-dione (Cas no. 524-38-9) with relevant read across which is structurally similar to target were summarized as follows: 

 

First prediction done using BCFBAF (v3.00) model and PBT profiler which indicate the estimated bio concentration factor (BCF) for 2-hydroxy-1H-isoindole-1,3(2H)-dione is 3.2 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that the substance is not expected to bio accumulate in the aquatic environment.

 

Above prediction is supported by data from Scifinder database which suggest the Bioconcentration factor (BCF) for target chemical 2-hydroxy-1H-isoindole-1,3(2H)-dione to be 6.32 to 6.37 at pH range 1-4, 5.90 at pH 5, 3.55  at pH 6, 1.0 at pH range 7-10 and temperature 25 deg.C.Based on the BCF concentration at all range of pH it is concluded that the test chemical 2-hydroxy-1H-isoindole-1,3(2H)-dione is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.

 

And Chemspider - ACD/PhysChem Suite prediction model indicate the Bioconcentration factor (BCF) for target chemical 2-hydroxy-1H-isoindole-1,3(2H)-dione to be 1.54 at pH 5.5 and 1 at pH 7.4 at temperature 25 deg.C. Based on the BCF concentration at two different pH concluded that the test chemical 2-hydroxy-1H-isoindole-1,3(2H)-dione is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.

Above all results for target are further supported by experimental data of read across chemical Phthalimide (Cas no. 85-41-6) wherein an estimated BCF value of 4.4 was calculated for phthalimide, using an experimental log Kow of 1.15 and a recommended regression derived equation. This BCF value suggests that bioconcentration in aquatic organisms will not be an important fate process.(HSDB database by US EPA;2017)

Thus based on all available studies for bioaccumulation endpoint concluded that the test substance 2-hydroxy-1H-isoindole-1,3(2H)-dione (Cas no. 524-38-9) is expected to be non Bioaccumulative in aquatic environment.

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