Registration Dossier

Diss Factsheets

Physical & Chemical properties

Melting point / freezing point

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-03-14 – 2017-03-14
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental result performed using standard methods of analysis
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Principles of method if other than guideline:
The melting point determination of Test item N-hydroxyphthalimide (CAS No. 524-38-9 ) was done as per the test guideline OECD 102. The method followed was according to Capillary/metal block
GLP compliance:
not specified
Type of method:
other: standard laboratory method
Specific details on test material used for the study:
- Name of test material:2-hydroxy-1H-isoindole-1,3(2H)-dione
- Molecular formula: C8H5NO3
- Molecular weight: 163.132 g/mol
- Smiles notation: c12c(C(=O)N(C1=O)O)cccc2
- Substance type: Organic
- Physical state: Solid
Melting / freezing pt.:
>= 230.8 - <= 233.6 °C
Atm. press.:
975.4 hPa
Decomposition:
no
Sublimation:
no
Remarks on result:
other: other details not available
Conclusions:
The melting point determination of 2-hydroxy-1H-isoindole-1,3(2H)-dione (CAS No. 524-38-9) was done following OECD Guideline 102 and according to the metal block capillary method. The test was conducted in replicates and mean melting temperature range was determined to be 230.8- 233.6°C at 975.4hPa
Executive summary:

The melting point determination of 2-hydroxy-1H-isoindole-1,3(2H)-dione (CAS No. 524-38-9) was done following OECD Guideline 102 and according to the metal block capillary method. The test was conducted in replicates and mean melting temperature range was determined to be 230.8- 233.6°C at 975.4hPa

Description of key information

The melting point determination of 2-hydroxy-1H-isoindole-1,3(2H)-dione (CAS No. 524-38-9) was done following OECD Guideline 102 and according to the metal block capillary method. The test was conducted in replicates and mean melting temperature range was determined to be 230.8- 233.6°C at 975.4hPa

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
230.8 °C

Additional information

The melting point determination of 2-hydroxy-1H-isoindole-1,3(2H)-dione (CAS No. 524-38-9) was done following OECD Guideline 102 and according to the metal block capillary method. The test was conducted in replicates and mean melting temperature range was determined to be 230.8- 233.6°C at 975.4hPa.

Other supporting studies from various reliable sources such as authoritative database and handbook also indicates that the melting point of chemical 2-hydroxy-1H-isoindole-1,3(2H)-dione was determined to be in the range of 223 degree C to 237 degree C.

As the data from lab has K1 reliability and the test was performed using OECD guidelines which has the value of melting temperature as 230.8 degree C to 233.6 degree C, thus considered as key study for the chemical safety assessment.

Categories Display