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Biodegradation in water

Estimation Programs Interface Suite was run to predict the biodegradation potential of the test compound Diphenyl acetonitrile (CAS no. 86 -29 -3) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical Diphenyl acetonitrile is expected to be not readily biodegradable.

Biodegradation in water and sediment

Estimation Programs Interface prediction model was run to predict the half-life in water and sediment for the test compound Diphenyl acetonitrile (CAS No. 86 -29 -3). If released in to the environment, 14.3% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of Diphenyl acetonitrile in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of Diphenyl acetonitrile in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 6% (i.e, reported as 5.21%), indicates that Diphenyl acetonitrile is not persistent in sediment.

 

Biodegradation in soil

The half-life period of Diphenyl acetonitrile (CAS No. 86 -29 -3) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database. If released into the environment, 80% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Diphenyl acetonitrile in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of Diphenyl acetonitrile, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Additional information

Biodegradation in water

Predicted data for the target compound Diphenyl acetonitrile (CAS No. 86-29-3) and various supporting weight of evidence studies for its structurally and functionally similar read across substance were reviewed for the biodegradation end point which are summarized as below:

 

In a prediction using the Estimation Programs Interface Suite, the biodegradation potential of the test compound Diphenyl acetonitrile (CAS no. 86 -29 -3) in the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical Diphenyl acetonitrile is expected to be not readily biodegradable.

 

In a supporting weight of evidence study from authoritative database (2018) for the test chemical,biodegradation experiment was conducted for 14 days for evaluating the percentage biodegradability of test substance. The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I) under aerobic conditions. Activated sludge (non-adapted) was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 0% by BOD and GC parameter in 14 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.

 

In an additional study,the test chemical was subjected to biodegradation test by taking activated sludge as inoculums at 30 mg/L concentration (J-CHECK, 2017). Biodegradation was analysed by using three parameter namely BOD, GC and UV-Vis. The initial concentration of test chemical was 100 mg/L. The test chemical showed 0% biodegradability by BOD parameter 6.5 % by GC parameter and 5.0 % by UV-Vis parameter by using activated sludge as inoculum in 14 days. On the basis of percent biodegradability it is concluded that test chemical is not readily biodegradable.

 

For the test chemical,biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance (authoritative database J-CHECK and EnviChem, 2016). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 1 and 19% by BOD and HPLC parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.

 

On the basis of above results for target chemical Diphenyl acetonitrile (from modelling database, 2018), it can be concluded that the test substance Diphenyl acetonitrile can be expected to be not readily biodegradable in nature.

Biodegradation in water and sediment

Estimation Programs Interface prediction model was run to predict the half-life in water and sediment for the test compound Diphenyl acetonitrile (CAS No. 86 -29 -3). If released in to the environment, 14.3% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of Diphenyl acetonitrile in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of Diphenyl acetonitrile in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 6% (i.e, reported as 5.21%), indicates that Diphenyl acetonitrile is not persistent in sediment.

 

Biodegradation in soil

The half-life period of Diphenyl acetonitrile (CAS No. 86 -29 -3) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database. If released into the environment, 80% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Diphenyl acetonitrile in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of Diphenyl acetonitrile, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

On the basis of available information, the test substance Diphenyl acetonitrile can be considered to be not readily biodegradable in nature.