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Hydrolysis

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical Diphenyl acetonitrile can be expected to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C, respectively or 6 years & 211 days at pH 7 and 8, respectively.

Additional information

Hydrolysis

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical Diphenyl acetonitrile. The studies are as mentioned below:

 

The half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.038 L/mol-sec with a corresponding half-lives of 6 yrs and 211 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that test chemical is not hydrolysable.

 

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C and pH of 4, 7 and 9, respectively. The average percentage recovery of the test chemical after 5 days was determined to be 96.5, 97.5 and 98.6% at pH 4, 7 and 9, respectively. As no hydrolysis of test chemical was observed for a period of 5 days, the half-lives was determined to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C, respectively. Based on the half-life values, it is concluded that test chemical is not hydrolysable.

 

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical Diphenyl acetonitrile can be expected to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C, respectively or 6 years & 211 days at pH 7 and 8, respectively.