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EC number: 944-207-2 | CAS number: -
In the initial 16h harvest there were statistically significant increases with dose in the % of aberrant cells for both activated and non activated tests. These trends were not reproducible in the repeat 16h harvest and were therefore not considered biologically significant.
In a mammalian cell cytogenetics assay [chromosome aberration], CHO cell cultures were exposed to a petroleum derived calcium salt derivative at concentrations of 0, 10, 20, 40, 80, 120 and 160 µg/ml with and without S9 metabolic activation.
Positive controls induced the appropriate response. There was no evidence of chromosome aberrations induced over background with the test substance.
This study is classified as acceptable. This study satisfies the requirement for Test Guideline OECD 473 for in vitro cytogenetic mutagenicity data.
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