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EC number: 944-207-2 | CAS number: -
SUMMARY OF REACTION:
At the 72 hour challenge patch reading, the subject exhibited 4-level erythema with severe dryness, severe oedema, and mild papules in contact site. Also there was a 2 level erythema with moderate, papular reaction, spreading about 1" beyond contact site.
At the 96 hour reading, the subject exhibited 3-level erythema with moderate vesiculation on the patch site, and a severe papular reaction covering approximately 1/2 of the upper back area.
At the 168 hour reading the subject exhibited 2-level erythema with moderate dryness and a moderate papular reaction, extending beyond the contact site covering approximately, 1/4 of the upper back.
At this point (168 hours) the reaction was subsiding and no further action was taken.
For the test subject's protection, a decision was made to patch anyone who reacted with a "2-level" or greater during induction semi-occlusively rather than occlusively during challenge.
To determine the irritation and/or sensitization potential of the test article after repeated application under occlusive patch test conditions to the skin of human subjects (non-exclusive panel). One hundred sixty-six (166) subjects, 26 males and 140 females, ranging in age from 19 to 68 years were empaneled for this test. The 9 Repeated Insult (occlusive) Patch Test (9 RIPT) was conducted.
Under the conditions, of the previouly described repeated insult patch test procedure, the test article: Calcium sulfonate (Total Base Number = 30) at 10% in Squibb Mineral Oil induced irritant responses on 26/142 (18.3%) of the test panellists who completed the study, and induced reactivity patterns that, in the opinion of the Principal Investigator, are suggestive of allergic contact dermatitis on 8/142 (5.6%) of the test panelists who completed the study.
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