2-Propenenitrile, reaction products with 1,3-benzenedimethanamine

Endpoint summary

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Reference

Endpoint:

skin irritation / corrosion

Remarks:

other: QSAR, read-across

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Principles of method if other than guideline:

TIMES Skin irritation/corrosion predictions and QSAR Toolbox read-across predictions

GLP compliance:

no

Irritation parameter:

other: QSAR, read-across

Basis:

other: QSAR, read-across

Remarks on result:

other: QSAR and read-across

Irritant / corrosive response data:

• The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified as Skin Corrosive Category 1 based on the predictions of constituents A and C.

·        The constituents of the UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineare predicted by using TIMES Skin irritation/corrosion model and Toolbox read-across analysis namely:

-       ConstituentsMXDA, A and C:Corrosive to skin;

-       Constituents B and D:Irritating to skin;

-       Constituent E:Non-irritating/corrosive to skin.

·        The predictions results are considered reliable:

1) they belong to the TIMES model's and Toolbox read-across prediction applicability domains.

2) they are supported by expert judgment.

·                      The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis classified asSkin Corrosive Category 1based on the predictions of constituents A and C.

Interpretation of results:

Category 1 (corrosive)

Remarks:

Migrated information H314 Criteria used for interpretation of results: EU

Conclusions:

The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified as Skin Corrosive Category 1 based on the predictions of constituents A and C. (H314)

Executive summary:

·        The constituents of the UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineare predicted by using TIMES Skin irritation/corrosion model and Toolbox read-across analysis namely:

-       ConstituentsMXDA, A and C:Corrosive to skin;

-       Constituents B and D:Irritating to skin;

-       Constituent E:Non-irritating/corrosive to skin.

·        The predictions results are considered reliable:

1) they belong to the TIMES model's and Toolbox read-across prediction applicability domains.

2) they are supported by expert judgment.

·                      The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis classified asSkin Corrosive Category 1based on the predictions of constituents A and C.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (corrosive)

Eye irritation

Link to relevant study records

Reference

Endpoint:

eye irritation

Remarks:

other: QSAR, read-across

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Principles of method if other than guideline:

• TIMES modeling approach (Eye irritation/corrosion)
• Toolbox 3.3 read-across analysis

GLP compliance:

no

Irritation parameter:

other: QSAR, read-across

Basis:

other: QSAR, read-across

Remarks on result:

other: QSAR, read-across

Read-across and QSAR prediction:

·        2-Propenenitrile, reaction products with 1,3-benzenedimethanamine constituents are predicted by using TIMES Eye irritationmodel and Toolbox Read-across byapplying worst case scenario,namely:

-       ConstituentsMXDA, A and C:Corrosive to eye;

-       Constituents B and D:Irritating to eye;

-       Constituent E:Non-irritating/corrosive to eye.

·        The predictions results are considered reliable:

1) they belong to the TIMES model's and Read-across prediction applicability domains

2) they are supported by expert judgment.

·        The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamine isclassified inhazard Category 1 (Eye Dam 1)based on the predictions of constituents A and C.

Interpretation of results:

Category I

Remarks:

Migrated information H318 Criteria used for interpretation of results: EU

Conclusions:

The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified in hazard Category 1 (Eye Dam 1) based on the predictions of constituents A and C.

Executive summary:

·        2-Propenenitrile, reaction products with 1,3-benzenedimethanamine constituents are predicted by using TIMES Eye irritationmodel and Toolbox Read-across byapplying worst case scenario,namely:

-       ConstituentsMXDA, A and C:Corrosive to eye;

-       Constituents B and D:Irritating to eye;

-       Constituent E:Non-irritating/corrosive to eye.

·        The predictions results are considered reliable:

1) they belong to the TIMES model's and Read-across prediction applicability domains

2) they are supported by expert judgment.

·        The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified in hazard Category 1 (Eye Dam 1)based on the predictions of constituents A and C.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Additional information

Justification for selection of skin irritation / corrosion endpoint:
Skin corrosion category 1 ( H314)

Justification for selection of eye irritation endpoint:
Eye corrosion category 1 ( H318)

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Justification for classification or non-classification

Skin corrosion category 1 ( H318)