Registration Dossier

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Prediction by OASIS Pimephales promelas LC50 96h and EPISUITE models and QSAR toolbox

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
1 480 mg/L

Additional information

Predicted results for Mortality LC50 96h Pimephales promelas from QSAR Toolbox were used for hazardassessment of2-Propenenitrile, reaction products with 1,3-benzenedimethanamine.

 All constituents of UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineare predicted asNarcotic aminesby QSAR.

  • Concentration Addition component-based approachwas implemented in QSAR Toolbox and used for acute aquatic toxicity to fish assessment of the mixture. This approach describes the joint action of compounds with an identical mode of action [13].

2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis predicted as a UVCB including constituents MXDA, A, B, C and D. The predicted value is1480 mg/L.The UVCB is not categorized based on the CLP and GHS classifications.