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EC number: 292-054-9 | CAS number: 90530-16-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: QSAR and read-across
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
- Principles of method if other than guideline:
- OASIS TIMES receptor-mediated models and QSAR Toolbox
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
- EC Number:
- 292-054-9
- EC Name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
- Cas Number:
- 90530-16-8
- IUPAC Name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
Constituent 1
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Based on:
- not specified
- Remarks:
- no data
- Sex:
- male/female
- Remarks on result:
- not measured/tested
- Remarks:
- no NOAEL identified Generation: QSAR and read-across prediction (migrated information)
Results: P1 (second parental generation)
Effect levels (P1)
- Dose descriptor:
- other: QSAR
- Remarks:
- QSAR
- Basis for effect level:
- other: QSAR test
- Remarks on result:
- not measured/tested
- Remarks:
- QSAR test
Results: F1 generation
Effect levels (F1)
- Dose descriptor:
- other: QSAR
- Remarks:
- QSAR
- Remarks on result:
- not measured/tested
- Remarks:
- QSAR
Results: F2 generation
Effect levels (F2)
- Dose descriptor:
- other: QSAR
- Remarks:
- QSAR
- Remarks on result:
- not measured/tested
- Remarks:
- QSAR
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
No NOAEL identified.
Applicant's summary and conclusion
- Conclusions:
- It is not classifed as toxicity to reproduction.
- Executive summary:
· TIMES Androgen and Estrogen Binding Affinityv.03modelsare used;
· The models are focused on the direct interactions of chemicals with the androgen and estrogen receptors (AR and ER) - that is, AR and ER binding mediated endocrine disruptions. These interactions are considered as primary events that trigger the ultimate biological responses;
2-Propenenitrile, reaction products with 1,3-benzenedimethanamineincluding constituents MXDA, A, B, C and D is predicted as not capable of eliciting interaction with androgen or estrogen receptors.
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