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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: QSAR and read-across
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Principles of method if other than guideline:
OASIS TIMES receptor-mediated models and QSAR Toolbox
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
EC Number:
292-054-9
EC Name:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
Cas Number:
90530-16-8
IUPAC Name:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Dose descriptor:
NOAEL
Based on:
not specified
Remarks:
no data
Sex:
male/female
Remarks on result:
not measured/tested
Remarks:
no NOAEL identified Generation: QSAR and read-across prediction (migrated information)

Results: P1 (second parental generation)

Effect levels (P1)

Dose descriptor:
other: QSAR
Remarks:
QSAR
Basis for effect level:
other: QSAR test
Remarks on result:
not measured/tested
Remarks:
QSAR test

Results: F1 generation

Effect levels (F1)

Dose descriptor:
other: QSAR
Remarks:
QSAR
Remarks on result:
not measured/tested
Remarks:
QSAR

Results: F2 generation

Effect levels (F2)

Dose descriptor:
other: QSAR
Remarks:
QSAR
Remarks on result:
not measured/tested
Remarks:
QSAR

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

No NOAEL identified.

Applicant's summary and conclusion

Conclusions:
It is not classifed as toxicity to reproduction.
Executive summary:

·        TIMES Androgen and Estrogen Binding Affinityv.03modelsare used;

·        The models are focused on the direct interactions of chemicals with the androgen and estrogen receptors (AR and ER) - that is, AR and ER binding mediated endocrine disruptions. These interactions are considered as primary events that trigger the ultimate biological responses;

2-Propenenitrile, reaction products with 1,3-benzenedimethanamineincluding constituents MXDA, A, B, C and D is predicted as not capable of eliciting interaction with androgen or estrogen receptors.