2-Propenenitrile, reaction products with 1,3-benzenedimethanamine

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2016

Report date:

2016

Materials and methods

Principles of method if other than guideline:

QSAR TOOLBOX - application of chemical category approach for predicting acute dermal toxicity

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-Propenenitrile, reaction products with 1,3-benzenedimethanamine

EC Number:

292-054-9

EC Name:

2-Propenenitrile, reaction products with 1,3-benzenedimethanamine

Cas Number:

90530-16-8

IUPAC Name:

2-Propenenitrile, reaction products with 1,3-benzenedimethanamine

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 1 492.53 mg/kg bw

Based on:

other: read-across category approach

Remarks on result:

other: read-across category approach

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information H312 Criteria used for interpretation of results: EU

Conclusions:

• Experimental LD50 dermal data is found for constituent MXDA. It is classified in the GHS acute toxicity hazard Category 5.
• Toolbox read-across analysis was used for acute dermal toxicity assessment of 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine constituents A, B, C, D and E. The performed read-across predictions were focused on the main chemical functionalities present in the target chemicals. Based on the worst case-scenario constituents A, B, and D are categorized in the Category 4 and constituents C and E are categorized as Category 5 according to the GHS classification.
• However, analysis of the structural analogues found in the literature classified constituents A to E in GHS Category 4.
• Based on the worst-case scenario read-across prediction and the applied additive formula for the acute dermal toxicity of UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is evaluated as 1492. 53 mg/kg. This value falls in GHS/CLP Category 4.

Executive summary:

2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis evaluated as LD50: 1492. 53 mg/kg. CLP: Acut tox dermal category 4 H312