Registration Dossier
Registration Dossier
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EC number: 292-054-9 | CAS number: 90530-16-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
- Principles of method if other than guideline:
- TIMES AMES model predictions and Toolbox read-across analyses
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
- EC Number:
- 292-054-9
- EC Name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
- Cas Number:
- 90530-16-8
- IUPAC Name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
Constituent 1
Results and discussion
Test results
- Species / strain:
- not specified
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Remarks:
- QSAR prediction
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: other: QSAR
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Based on the experimental data for structural analogues, TIMES AMES model predictions and Toolbox read-across analyses, the UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is ultimately predicted as in vitro Ames negative, i.e. not capable of eliciting mutagenicity.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative Not classified as mutagen.
Not classified as mutagen. - Executive summary:
Based on the experimental data for structural analogues, TIMES AMES model predictions and Toolbox read-across analyses, theUVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis ultimately predicted as in vitro Ames negative, i.e. not capable of eliciting mutagenicity.
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