Registration Dossier
Registration Dossier
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EC number: 700-208-8 | CAS number: -
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- no further testing for developmental toxicity is necessary because the substance is known to cause developmental toxicity, meeting the criteria for classification as toxic for reproduction category 1A or 1B: May damage the unborn child (H360D), and the available data are adequate to support a robust risk assessment and the classification and labelling of the substance
- Justification for type of information:
- Clear indication for adverse effect on fertility and development of F1 pups was observed in the screening study. According to above classification criteria there was “clear evidence” for developmental toxicity. Since no serious deficiencies in study design can be located classification of N-((3(5)-Methyl-1H-pyrazol-1-yl)methyl)acetamid into category 1B is most appropriate.
Therefore no further testing is required.
Data source
Materials and methods
Test animals
- Species:
- rat
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
