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EC number: 700-208-8 | CAS number: -
Observed grades of skin alterations at each observation time
hours after administration
The acute dermal irritation/corrosion of N-(3(5)-Methyl-1H-pyrazol-l-yl-methyl)- acetamid (P 70/05) was tested in three albino rabbits according to OECD Guideline 404 (Acute Dermal Irritation / Corrosion). The test item was applied as the original substance after grinding in a mortar at a dose of 0.5 g to a shaved dorsal area of trunk and covered with a gauze patch and aluminium foil which was held in contact with the skin with an occlusive dressing. The test was started with one rabbit with exposure periods of three minutes, one hour and four hours. Because no serious skin reaction was observed in this animal the result was confirmed using two further animals with a four-hour exposure. After each exposure the administration area was cleaned with deionised water.
Animals were examined for mortality, clinical signs and signs of irritation response 60 minutes, 24, 48, 72 hours after patch removal. The grading of skin reaction given in the guideline was used for the evaluation of the dermal irritation.
The administration of 0.5 g of N-(3(5)-Methyl-lH-pyrazoM-yl-methyl)-acetamid (P 70/05)
to shaved dorsal area of the trunk of albino rabbits did not cause any skin irritation at any observation time.
No systemic toxic effects were observed.
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