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EC number: 700-208-8 | CAS number: -
The acute eye irritation/corrosion of N-(3(5)-Methyl-1H-pyrazoI-l-yl-methyl)-acetamid (P 70/05) was tested in three albino rabbits according to OECD Guideline 405 (Acute Eye Irritation / Corrosion). The test item was instilled as the original substance at a single dose of 0.1 ml to one of the eyes in each animal. The untreated eye was used as control.
The animals were examined for clinical signs and the eyes were examined for lesions of the conjunctivae, cornea and iris 60 minutes, 24, 48 and 72 hours and from day 4 till day 14 after instillation of the test item. The grades for ocular lesions were recorded in accordance with the guideline.
A single instillation of N-(3(5)-Methyl-lH-pyrazol-l-yl-methyl)-acetamid (P 70/05) into the conjunctival sac of three albino rabbits caused a damage of the epithelia of the cornea, slight effects to the iris, slight to moderate redness and swelling of the conjunctivae and a purulent secretion from the eye. All effects were reversible within an observation period of 13 days. None of the animals died or showed clinical signs during the course of testing. The alterations of the eyes after instillation of N-(3 (5)-Methyl-1 H-pyrazol-1 -yl-methyl)- acetamid (P 70/05) meet the criteria for classification as an eye irritant.
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