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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2009-01-13 - 2009-03-11
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The GLP study was conducted according to an internationally accepted guideline. All study parameters are based on the specific guideline.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
178.14 g/L
Temp.:
20 °C
pH:
> 8.12 - < 8.71

Plateau

Vessel

Sample Volume

Dilution

Absorption

Concentration

pH

Temperature

 

μL

Factor

at 220nm

g/L

 

in °C

1

10

10000

0.7464

177.15

8.12

20.2

2

10

10000

0.7520

178.95

8.71

20.2

3

10

10000

0.7432

176.88

8.65

20.2

4

10

10000

0.7403

176.19

8.60

20.2

5

10

10000

0.7611

181.09

8.51

20.2

6

10

10000

0.7503

178.55

8.35

20.2

Conclusions:
Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of N-[(3(5)-Methyl-1 H-pyrazol-1 -yl)-methyl]acetamide was determined according to OECD Guideline 105. The determination of the water solubility of the test item was performed using the shake flask method.
After mixing 100 mg test item, respectively, with 0.1, 0.5, 1 and 2 mL H20, the test item was found completely dissolved by 2 mL (visual judgement); solubility of the test item in water could be estimated as approx. 50 g/L or higher.
In the main study, 2.5 ± 1 g were weighed into each of six individual vessels, 10 mL water were added, and the vessels were shaken.
On the days 1, 2, and 3, vessel 1 was taken from the shaking apparatus and stored for equilibration. Samples were taken, centrifuged and analysed by UVA/IS photometry at 220 nm as shaking of the test vessels was continued.
No differences above 2% in the concentration of the solution could be determined between the sampling dates 1, 2, and 3, supporting the hypothesis, that the maximum concentration of the test item had been reached. Therefore, on day 3, vessels 1 - 6 were sampled and analysed in the same fashion
At the plateau, the concentration of the test item in water had reached
178.14 ± 1.782 g/L at 20 ± 0.5 °C corresponding to 0.17814 ± 0.00182 * kg/m3
(mean value ± standard deviation of six individual vessels)
Executive summary:

The water solubility of N-[(3(5)-Methyl-1 H-pyrazol-1 -yl)-methyl]acetamide was determined according to OECD Guideline 105. The determination of the water solubility of the test item was performed using the shake flask method. After mixing 100 mg test item, respectively, with 0.1, 0.5, 1 and 2 mL H20, the test item was found completely dissolved by 2 mL (visual judgement); solubility of the test item in water could be estimated as approx. 50 g/L or higher. In the main study, 2.5 ± 1 g were weighed into each of six individual vessels, 10 mL water were added, and the vessels were shaken. On the days 1, 2, and 3, vessel 1 was taken from the shaking apparatus and stored for equilibration. Samples were taken, centrifuged and analysed by UVA/IS photometry at 220 nm as shaking of the test vessels was continued. No differences above 2% in the concentration of the solution could be determined between the sampling dates 1, 2, and 3, supporting the hypothesis, that the maximum concentration of the test item had been reached. Therefore, on day 3, vessels 1 - 6 were sampled and analysed in the same fashion. At the plateau, the concentration of the test item in water had reached 178.14 ± 1.782 g/L at 20 ± 0.5 °C corresponding to 0.17814 ± 0.00182 * kg/m3 (mean value ± standard deviation of six individual vessels).

Description of key information

The water solubility of N-[(3(5)-Methyl-1 H-pyrazol-1 -yl)-methyl]acetamide was determined according to OECD Guideline 105. The determination of the water solubility of the test item was performed using the shake flask method. A water solubility of  178.14 ± 1.782 g/L at 20 ± 0.5 °C was estimated.

Key value for chemical safety assessment

Water solubility:
178.14 g/L
at the temperature of:
20 °C

Additional information

A water solubility of 178.14 ± 1.782 g/L at 20 ± 0.5 °C was estimated.