Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

INHALATION
None specific.

INGESTION
None specific

SKIN CONTACT
May cause a photo sensitisation.

EYE CONTACT
None specific. Rinse eye with plenty of low pressure water for at least 15 minutes. Remove any contact lenses.

Fire-fighting measures

EXTINGUISHING MEDIA
Flashpoint 171 °C
To extinguish fire use water spray, dry powder, carbon dioxide, or foam.

SPECIAL FIRE FIGHTING PROCEDURES
Prevent run-off water from entering the sewer system.

UNUSUAL FIRE & EXPLOSION HAZARDS
None.

SPECIFIC HAZARDS
By fire toxic gases may be formed (Cox, NOx).

PROTECTIVE MEASURES IN FIRE
Self contained breathing apparatus and full protective clothing.

Accidental release measures

PERSONAL PRECAUTIONS
See below.

ENVIRONMENTAL PRECAUTIONS
Take precautionary measures against discharges into the environment.

SPILL CLEAN UP METHODS
Collect spilled material without creating dust, then place into a suitable closed container for disposal as chemical waste.

Handling and storage

USAGE PRECAUTIONS
Avoid contact with eyes or skin.
Wash thoroughly after handling and before eating, drinking or smoking.

STORAGE PRECAUTIONS
To protect product quality, store in sealed container in a cool, dry and dark place.

Transport information

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Marine transport (IMDG)

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Exposure controls / personal protection

EXPOSURE LIMITS
None listed.

USE LIMITS
Only to be handled in an industrial environment as industrial feedstock for further chemical synthesis

PNECs:
aqua-freshwater: 0.0337 mg/L
aqua-marine water: 0.00337 mg/L
aqua-intermittent: 0.337 mg/L
sewage treatment plant: 48.7 mg/L
sediment-freshwater: 0.115 mg /kg dw
sediment-marine water: 0.0115 mg /kg dw
soil: 10 mg /kg dw

DNELs:
The main derived long-term DNELs for systemic effects are:
Workers General population
Oral not relevant 6 mg/kg bw/day
Dermal 12 mg/kg bw/day 6 mg/kg bw/day
Inhalation 10.59 mg/m3/day 2.61 mg/m3/day

The CHESAR v2.3.0 exposure model for this substance shows for indoor industrial activities taking more than 4 hours/day, with local exhaust ventilation (LEV) present (and running), the following exposures:

Inhalation (mg/m3) dermal (mg/kg/day) RCR (inh) RCR (dermal) RCR (total)
PROC1 0.01 0.034 < 0.01 < 0.01 < 0.01
Use in closed process, no likelihood of exposure
PROC2 0.001 0.137 < 0.01 0.011 0.012
Use in closed, continuous process with occasional controlled exposure
PROC3 0.01 0.069 < 0.01 < 0.01 < 0.01
Use in closed batch process (synthesis or formulation)
PROC8b 0.005 0.685 < 0.01 0.057 0.058
Transfer of chemicals from/to vessels/large containers at dedicated facilities
PROC9 0.01 0.686 < 0.01 0.057 0.058
Transfer of chemicals into small containers (dedicated filling line)
PROC15 0.01 0.034 < 0.01 < 0.01 < 0.01
Use as a laboratory reagent

Notes:
• Dustiness of the substance was set at “low”
• Basic general ventilation is assumed in all cases (1-3 air exchanges per hour)
• An advanced occupational health and safety management system has been assumed
• LEV is considered for both inhalation and dermal exposures and its efficiencies are as follows:
o For PROC1 LEV is not an exposure modifier
o For PROC2, PROC3, PROC9 and PROC15 LEV reduces both inhalation and dermal exposure with 90%
o For PROC8b LEV reduces both inhalation and dermal exposure with 95%

PROTECTIVE EQUIPMENT
Protective gloves, safety goggles, and protective clothing.

RESPIRATORY EQUIPMENT
None required

HAND PROTECTION
Protective gloves: Use chemical resistant gloves classified under Standard EN374, class 6.

EYE PROTECTION
Wear approved safety goggles.

HYGIENE MEASURES
Wash at the end of each work shift and before eating, drinking, smoking or using the toilet.

SKIN PROTECTION
Wear protective clothing.

Stability and reactivity

STABILITY
Stable under normal temperature conditions and recommended use.

MATERIALS TO AVOID
Strong oxidising agents, strong acids, acid chlorides, acid anhydrides.

HAZARDOUS DECOMPOSITION PRODUCTS
By fire toxic gases (Cox, NOx) may be formed.

Disposal considerations

GENERAL INFORMATION
Place into a suitable closed container for disposal as chemical waste.

DISPOSAL METHODS
Dispose of in accordance with local and national regulations.