Registration Dossier
Registration Dossier
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EC number: 205-753-0 | CAS number: 150-13-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- No information
- Author:
- European Commission
- Year:
- 2 006
- Bibliographic source:
- SCCP/1008/06
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
- GLP compliance:
- no
- Type of assay:
- in vitro mammalian chromosome aberration test
Test material
- Reference substance name:
- 4-aminobenzoic acid
- EC Number:
- 205-753-0
- EC Name:
- 4-aminobenzoic acid
- Cas Number:
- 150-13-0
- Molecular formula:
- C7H7NO2
- IUPAC Name:
- 4-aminobenzoic acid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- 1500/1700/1900 microgram/ml
- Vehicle / solvent:
- DMSO
Controls
- Untreated negative controls:
- no
- True negative controls:
- no
- Positive controls:
- yes
Results and discussion
Test results
- Species / strain:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Remarks:
- at the higest dose only
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive without metabolic activation
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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