Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Title:
No information
Author:
European Commission
Year:
2006
Bibliographic source:
SCCP/1008/06

Materials and methods

Test guideline
Guideline:
other: no data
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-aminobenzoic acid
EC Number:
205-753-0
EC Name:
4-aminobenzoic acid
Cas Number:
150-13-0
Molecular formula:
C7H7NO2
IUPAC Name:
4-aminobenzoic acid

Test animals

Species:
human

Test system

Type of coverage:
occlusive
Vehicle:
other: a sunscreen formulation
Controls:
yes
Amount / concentration applied:
5% in vehicle
Duration of treatment / exposure:
48 h
Observation period:
96 h
Number of animals:
50

Results and discussion

In vivo

Results
Irritation parameter:
other: see SCCP report
Basis:
mean
Time point:
other: 96 h
Score:
0
Max. score:
70
Remarks on result:
other: 5% solution of the substance in a sunscreen formulation

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU