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Key value for chemical safety assessment

Genetic toxicity in vitro

Link to relevant study records
Reference
Endpoint:
in vitro cytogenicity / chromosome aberration study in mammalian cells
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Guideline:
OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
GLP compliance:
no
Type of assay:
in vitro mammalian chromosome aberration test
Species / strain / cell type:
Chinese hamster Ovary (CHO)
Metabolic activation:
without
Test concentrations with justification for top dose:
1500/1700/1900 microgram/ml
Vehicle / solvent:
DMSO
Untreated negative controls:
no
True negative controls:
no
Positive controls:
yes
Species / strain:
Chinese hamster Ovary (CHO)
Metabolic activation:
without
Genotoxicity:
positive
Remarks:
at the higest dose only
Cytotoxicity / choice of top concentrations:
not specified
Conclusions:
Interpretation of results (migrated information):
positive without metabolic activation
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (positive)

Additional information

Additional information from genetic toxicity in vitro:

PABA did not induce mutations in bacteria, but induced an increased incidence of chromosome

aberrations in CHO cells at 1900 μg/ml (the highest dose tested; no scoreable metaphases could

be found at higher doses).

Justification for classification or non-classification

A classification for this endpoint is not required