Registration Dossier
Registration Dossier
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EC number: 200-908-9 | CAS number: 75-85-4
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature (handbook)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Patty's Industrial Hygiene and Toxicology
- Author:
- Rowe and McCollister
- Year:
- 1 982
- Bibliographic source:
- Clayton and Clayton (eds.), Vol.2C, 3rd ed. (1982), John Wiley & Sons, New York, 4604 - 4605, 4608, 4701
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Sensitization test according to Maguire (modified)
- GLP compliance:
- not specified
- Type of study:
- other: Maguire method
Test material
- Reference substance name:
- 2-methylbutan-2-ol
- EC Number:
- 200-908-9
- EC Name:
- 2-methylbutan-2-ol
- Cas Number:
- 75-85-4
- Molecular formula:
- C5H12O
- IUPAC Name:
- 2-methylbutan-2-ol
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Vehicle:
- no data
- Concentration / amount:
- undiluted
Challengeopen allclose all
- Vehicle:
- no data
- Concentration / amount:
- undiluted
- No. of animals per dose:
- 10 animals
- Positive control substance(s):
- yes
- Remarks:
- Positive control group
Results and discussion
- Positive control results:
- All 10 animals showed sensitizing effects
Any other information on results incl. tables
When a group of 10 animals was tested with undiluted test substance none was sensitized (whereas all 10 of positive control group were sensitized).
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the present study the test item is not a skin sensitiser.
- Executive summary:
The skin sensitizing potential of the test item was determined. A group of 10 guinea pigs was tested with undiluted test substance. No sensitizing effects were observed. All 10 animals in the positive group showed sensitizing effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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