Registration Dossier
Registration Dossier
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EC number: 200-908-9 | CAS number: 75-85-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Patty's Industrial Hygiene and Toxicology
- Author:
- Rowe and McCollister
- Year:
- 1 982
- Bibliographic source:
- Clayton and Clayton (eds.), Vol.2C, 3rd ed. (1982), John Wiley & Sons, New York, 4604 - 4605, 4608, 4701
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute dermal toxicity, no further details
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2-methylbutan-2-ol
- EC Number:
- 200-908-9
- EC Name:
- 2-methylbutan-2-ol
- Cas Number:
- 75-85-4
- Molecular formula:
- C5H12O
- IUPAC Name:
- 2-methylbutan-2-ol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- Control animals:
- not specified
- Details on study design:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 720 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no data
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal toxicity of the test item was determined. The LD50 value was determined to be 1720 mg/kg bw.
- Executive summary:
The acute dermal toxicity of the test item was determined. The test item was applicated occlusively as standard acute method. The rabbits were exposed to the test material over a period of 24 hours. The LD50 value was determined to be 1720 mg/kg bw.
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