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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable publication

Data source

Reference
Reference Type:
publication
Title:
The Metabolism of Aliphatic Alcohols. The Glucoronic Acid Conjugation of Acyclic Aliphatic Alcohols
Author:
Kamil, I.A. et al.
Year:
1953
Bibliographic source:
Biochem. 53, 129 - 136

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
not specified

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on exposure:
single exposure
Doses / concentrations
Remarks:
Doses / Concentrations:
441 mg/kg bw
Control animals:
not specified

Results and discussion

Main ADME resultsopen allclose all
Type:
excretion
Results:
After a single gavage of 441 mg/kg bw test item to rabbits 57.5 % was urinary excreted within 2 days p.a.
Type:
metabolism
Results:
The substance as a conjugate with glucuronic acid was identified in urine

Toxicokinetic / pharmacokinetic studies

Details on excretion:
After a single gavage of 441 mg/kg bw test item to rabbits 57.5 % was urinary excreted within 2 days p.a.

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
The substance as a conjugate with glucuronic acid was identified in urine

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
The toxicokinetic behaviour of the test item was examined. After a single gavage of 441 mg/kg bw of the test item to rabbits 57.5 % was urinary excreted within 2 days p.a. The substance as a conjugate with glucuronic acid was identified in urine.
Executive summary:

The toxicokinetic behaviour of the test item was examined. A single exposure was given to rabbits to determine the metabolism of the test item. After a single gavage of 441 mg/kg bw of the test item to rabbits 57.5 % was urinary excreted within 2 days p.a. The substance as a conjugate with glucuronic acid was identified in urine.