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EC number: 200-908-9 | CAS number: 75-85-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: Three disregarded studies are available. No conclusion can be made based on these studies. According to the ECHA disseminated dossier the LD50 male/female was determined to be 5184 mg/kg bw in a acute oral toxicity equivalent to OECD guideline 401. The LD50 value male was determined to be >5184 mg/kg bw and the LD50 female was determined to be 4050 mg/kg bw.
Acute inhalation toxicity: The acute inhalation toxicity of the test item was determined. The LD50 was determined to be between 20.6 and 10.8 mg/L.
Acute dermal toxicity: The acute dermal toxicity of the test item was determined. The LD50 value was determined to be 1720 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- Documentation insufficient for assessment
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute inhalation toxicity, no further details
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 6 h
- Concentrations:
- Nominal concentrations: 15800; 5700; 3000 and 1100 ppm (57; 20.6; 10.8; 4 mg/L)
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LC100
- Effect level:
- 5 700 ppm
- Exp. duration:
- 6 h
- Remarks on result:
- other: 20.6 mg/L
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- >= 3 000 - <= 5 700 ppm
- Exp. duration:
- 6 h
- Remarks on result:
- other: between 20.6 and 10.8 mg/L
- Mortality:
- At top level all animals dead.
5700 ppm: All were dead within 24 hours - Clinical signs:
- other: Motor incoordination
- Body weight:
- Loss of body weight
- Gross pathology:
- no data
- Other findings:
- no data
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute inhalation toxicity of the test item was determined. The LD50 was determined to be between 3000 and 5700 ppm (equivalent to 10990.556 and 20882.057 mg/m^3)
- Executive summary:
The acute inhalation toxicity of the test item was determined. The standard acute method was conducted with 4 rats. Nominal concentration of 15800, 5700, 3000 and 1100 ppm (57, 20.6, 10.8 and 4 mg/L) were used. The rats were exposed to the test item over a period of 6 h. As a result the LC100 was determined to be 5700 ppm and the LC50 was determined to be between 3000 and 5700 ppm (equivalent to 10990.556 and 20882.057 mg/m^3). Furthermore at the top level, all animals exhibited motor incoordination within 90 min. and all were dead within 3 hours. 5700 ppm (20.6 mg/L): Those exposed to 5700 ppm were unconscious at the end of exposure and died within 24 hours. Deaths were believed to be due to respiratory failure. 3000 ppm (10.8 mg/L): The rats exposed to 3000 ppm were als unconscious at the end of the exposure, lost weight for a few days and then recovered and survived. 1100 ppm (4 mg/L): Those exposed to 1100 ppm exhibited slight motor inccordination at the end of the exposure, appeared normal 24 hours later, experienced no weight loss and survived.
Reference
15800 ppm (57 mg/L) : At the top level, all animals exhibited motor incoordination within 90 min. and all were dead within 3 hours. 5700 ppm (20.6 mg/L): Those exposed to 5700 ppm were unconscious at the end of exposure and died within 24 hours. Deaths were believed to be due to respiratory failure. 3000 ppm (10.8 mg/L): The rats exposed to 3000 ppm were als unconscious at the end of the exposure, lost weight for a few days and then recovered and survived. 1100 ppm (4 mg/L): Those exposed to 1100 ppm exhibited slight motor inccordination at the end of the exposure, appeared normal 24 hours later, experienced no weight loss and survived.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 10 990.556 mg/m³
- Quality of whole database:
- Only secondary literature available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute dermal toxicity, no further details
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- Control animals:
- not specified
- Details on study design:
- no data
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 720 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no data
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal toxicity of the test item was determined. The LD50 value was determined to be 1720 mg/kg bw.
- Executive summary:
The acute dermal toxicity of the test item was determined. The test item was applicated occlusively as standard acute method. The rabbits were exposed to the test material over a period of 24 hours. The LD50 value was determined to be 1720 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 720 mg/kg bw
- Quality of whole database:
- only secondary literature
Additional information
Acute oral toxicity
Munch, J.C. (1972)
The acute oral toxicity of the test item was determined. The publication is classified as disregarded study with insufficient documentation for assessment. A LD50 value (rabbits) of 2027 mg/kg bw was determined.
Schaffarzick, R.W., Brown, B.J. (1952)
The acute oral toxicity of the test item was determined. The publication was classified as disregarded study because of insufficient documentation for assessment. The LD50 with rats was determined to be 1000 mg/kg bw.
Rowe and McCollister (1982)
The acute oral toxicity of the test item was determined. The study is classified as disregarded study. The LD50 with rats was determined to be between 1000 and 2000 mg/kg bw.
Acute inhalation toxicity
The acute inhalation toxicity of the test item was determined. The standard acute method was conducted with 4 rats. Nominal concentration of 15800, 5700, 3000 and 1100 ppm (57, 20.6, 10.8 and 4 mg/L) were used. The rats were exposed to the test item over a period of 6 h. As a result the LC100 was determined to be 5700 ppm and the LC50 was determined to be between 3000 and 5700 ppm (equivalent to 10990.556 and 20882.057 mg/m^3). Furthermore at the top level, all animals exhibited motor incoordination within 90 min. and all were dead within 3 hours. 5700 ppm (20.6 mg/L): Those exposed to 5700 ppm were unconscious at the end of exposure and died within 24 hours. Deaths were believed to be due to respiratory failure. 3000 ppm (10.8 mg/L): The rats exposed to 3000 ppm were all unconscious at the end of the exposure, lost weight for a few days and then recovered and survived. 1100 ppm (4 mg/L): Those exposed to 1100 ppm exhibited slight motor inccordination at the end of the exposure, appeared normal 24 hours later, experienced no weight loss and survived.
Acute dermal toxicity
The acute dermal toxicity of the test item was determined. The test item was applied occlusively as standard acute method. The rabbits were exposed to the test material over a period of 24 hours. The LD50 value was determined to be 1720 mg/kg bw.
Justification for selection of acute toxicity – oral endpoint
Documentation insufficient for assessment
Justification for selection of acute toxicity – inhalation endpoint
Only secondary literature available
Justification for selection of acute toxicity – dermal endpoint
only secondary literature
Justification for classification or non-classification
Classification, Labelling, and Packaging
Regulation according to Annex VI of Regulation (EC) 1272/2008
According to the harmonised Annex VI classification the substance is
considered to be classified for acute inhalation toxicity cat. 4, H332
and STOT Single Exp. 3, H335 under Regulation (EC) No 1272/2008,.
Self-Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data is reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. Based on the results the substance is considered to be classified as acute dermal toxicity category 4., H312, acute inhalation toxicity cat. 4 H332 and STOT Single Exp. 3 H335 under Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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