Registration Dossier
Registration Dossier
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EC number: 200-908-9 | CAS number: 75-85-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature (handbook)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Patty's Industrial Hygiene and Toxicology
- Author:
- Rowe and McCollister
- Year:
- 1 982
- Bibliographic source:
- Clayton and Clayton (eds.), Vol.2C, 3rd ed. (1982), John Wiley & Sons, New York, 4604 - 4605, 4608, 4701
Materials and methods
- Principles of method if other than guideline:
- Method: other: instillation of the undiluted test item into the rabbit eye.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-methylbutan-2-ol
- EC Number:
- 200-908-9
- EC Name:
- 2-methylbutan-2-ol
- Cas Number:
- 75-85-4
- Molecular formula:
- C5H12O
- IUPAC Name:
- 2-methylbutan-2-ol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
Results and discussion
In vivo
- Irritant / corrosive response data:
- Irritating
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The eye irritation potential of the test item was determined. Irritating effects were observed.
- Executive summary:
The eye irritation potential of the test item was determined by instillation of the undiluted test item into the rabbit eye. Irritating effects were observed during the study. No further information are given.
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