Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Assessment of the Developmental Toxicity of Ethylene Glycol Applied Cutaneously to CD-1 Mice.
Author:
Tyl RW, Fisher LC, Kubena MF, Vrbanic MA, Losco PE
Year:
1995
Bibliographic source:
Fundamental and Applied Toxicology 27: 155-166
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report Date:
1988

Materials and methods

Principles of method if other than guideline:
LD50 derived from developmental toxicity study.
GLP compliance:
yes
Test type:
other: LD50 derived from developmental toxicity study
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
CD-1
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
water
Duration of exposure:
see developmental toxicity/teratogenicity
Doses:
approx. 404, 1677 and 3549 mg/kg bw
No. of animals per sex per dose:
see developmental toxicity/teratogenicity
Control animals:
yes

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 3 500 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met