Registration Dossier
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EC number: 203-473-3 | CAS number: 107-21-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
From the available test data in combination with QSAR calculations it can be concluded, that the members of the ethylene category shows a very low toxicity to aquatic algae.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 100 mg/L
Additional information
Within the category of 'ethylene glycol and higher glycols' data on the toxicity for aquatic algae are available for four substances ethylene glycol (CAS-No.: 107-21-1), diethylene glycol (CAS-No.: 111-46-6) , triethylene glycol (CAS-No.: 112-27-6) and pentaethylene glycol (CAS-No.: 4792-15-8).
For three substances (CAS-No.: 107-21-1, 111-46-6, 112-27-6) 8 days cell growth inhibition tests with the green algae Scenedesmus quadricauda were conducted according to the method described from Bringmann & Kühn (1977/78). The reported toxic threshold concentrations, which are comparable with an EC5 value ranged between 2700 mg/L for diethylene glycol and >10000 mg/L for ethylene glycol and triethylene glycol.
For ethylene glycol a further study with Selenastrum capricornutum is available, which was conducted according to EPA standards. After 96 hours of exposure an EC50 value of 6500-13000 mg/L is reported [Dow, 1982].
Furthermore, one study according to OECD guideline 201 is availablefor pentaethylene glycol. In this study the green algae Pseudokirchnerella subcapitata was exposed for 72 hours in a limit test with a test concentration of 100 mg/L. No effects on the growth rate of the algae were determined [Mead & McKenzie, 2003 – cited in OECD SIDS 2004].
For each category member the expected long-term toxicity to green algae was additionally calculated with the QSAR EpiWin-Program ECOSAR v1.11. Based on the results of the estimations a very low chronic toxicity has to be expected for all category members. The calculated chronic value (ChV) for ethylene glycol (CAS-No.: 107-21-1) is 479 mg/L [BASF SE, 2013].
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