Registration Dossier
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EC number: 203-473-3 | CAS number: 107-21-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
From the available test data in combination with QSAR calculations it can be concluded, that the members of the ethylene category shows a very low toxicity to aquatic algae.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 100 mg/L
Additional information
Within the category of 'ethylene glycol and higher glycols' data on the toxicity for aquatic algae are available for four substances ethylene glycol (CAS-No.: 107-21-1), diethylene glycol (CAS-No.: 111-46-6) , triethylene glycol (CAS-No.: 112-27-6) and pentaethylene glycol (CAS-No.: 4792-15-8).
For three substances (CAS-No.: 107-21-1, 111-46-6, 112-27-6) 8 days cell growth inhibition tests with the green algae Scenedesmus quadricauda were conducted according to the method described from Bringmann & Kühn (1977/78). The reported toxic threshold concentrations, which are comparable with an EC5 value ranged between 2700 mg/L for diethylene glycol and >10000 mg/L for ethylene glycol and triethylene glycol.
For ethylene glycol a further study with Selenastrum capricornutum is available, which was conducted according to EPA standards. After 96 hours of exposure an EC50 value of 6500-13000 mg/L is reported [Dow, 1982].
Furthermore, one study according to OECD guideline 201 is availablefor pentaethylene glycol. In this study the green algae Pseudokirchnerella subcapitata was exposed for 72 hours in a limit test with a test concentration of 100 mg/L. No effects on the growth rate of the algae were determined [Mead & McKenzie, 2003 – cited in OECD SIDS 2004].
For each category member the expected long-term toxicity to green algae was additionally calculated with the QSAR EpiWin-Program ECOSAR v1.11. Based on the results of the estimations a very low chronic toxicity has to be expected for all category members. The calculated chronic value (ChV) for ethylene glycol (CAS-No.: 107-21-1) is 479 mg/L [BASF SE, 2013].
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