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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
other: abstract
Title:
Comparative pharmacokinetics and metabolism of ethylene glycol in pregnant rats and rabbits.
Author:
Carney EW, Pottenger LH, Bartels MJ, Jaeckh R, Quast JF
Year:
1998
Bibliographic source:
Toxicology Letters 95: 208

Materials and methods

Test guideline
Qualifier:
no guideline followed

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethane-1,2-diol
EC Number:
203-473-3
EC Name:
Ethane-1,2-diol
Cas Number:
107-21-1
Molecular formula:
C2H6O2
IUPAC Name:
ethane-1,2-diol

Test animals

Species:
other: rat and rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Duration and frequency of treatment / exposure:
gd 10 rats and gd 9
Doses / concentrationsopen allclose all
Dose / conc.:
500 mg/kg bw/day
Dose / conc.:
2 500 mg/kg bw/day
Control animals:
not specified

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parameters
Key result
Toxicokinetic parameters:
other: Key findings: (1)maternal blood concentrations of EG were comparable in rats and rabbits; (2)levels of GA in maternal blood and EEF were 3 to 36-fold lower in rabbits than in rats; (3)in rats, concentrations of GA were higher in EEF than in maternal blood

Applicant's summary and conclusion