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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
other: abstract
Title:
Comparative pharmacokinetics and metabolism of ethylene glycol in pregnant rats and rabbits.
Author:
Carney EW, Pottenger LH, Bartels MJ, Jaeckh R, Quast JF
Year:
1998
Bibliographic source:
Toxicology Letters 95: 208

Materials and methods

Test guideline
Qualifier:
no guideline followed

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: rat and rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Duration and frequency of treatment / exposure:
gd 10 rats and gd 9
Doses / concentrationsopen allclose all
Dose / conc.:
500 mg/kg bw/day
Dose / conc.:
2 500 mg/kg bw/day
Control animals:
not specified

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parameters
Key result
Toxicokinetic parameters:
other: Key findings: (1)maternal blood concentrations of EG were comparable in rats and rabbits; (2)levels of GA in maternal blood and EEF were 3 to 36-fold lower in rabbits than in rats; (3)in rats, concentrations of GA were higher in EEF than in maternal blood

Applicant's summary and conclusion