Registration Dossier
Registration Dossier
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EC number: 203-473-3 | CAS number: 107-21-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Early study report, short study description.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- according to BASF-internal standards
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Ethane-1,2-diol
- EC Number:
- 203-473-3
- EC Name:
- Ethane-1,2-diol
- Cas Number:
- 107-21-1
- Molecular formula:
- C2H6O2
- IUPAC Name:
- ethane-1,2-diol
Constituent 1
- Specific details on test material used for the study:
- 30% solution in aqua dest.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 3200, 6400, 8000, 10000 mL/Kg bw
- No. of animals per sex per dose:
- 20
- Control animals:
- no
- Details on study design:
- Recording of symptoms for 7 days after application.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 7 712 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Dead animals after 7 days observation period:
19/20 in 10000 mL/kg bw dose group
16/20 in 8000 mL/kg bw dose group
5/20 in 6400 mL/kg bw dose group
0/20 in 3200 mL/kg bw dose group - Clinical signs:
- other: depression, narcosis.
- Gross pathology:
- Animals that died: kidney damage
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
