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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Early study report, short study description.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1968
Report Date:
1968

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
according to BASF-internal standards
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
30% solution in aqua dest.

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
3200, 6400, 8000, 10000 mL/Kg bw
No. of animals per sex per dose:
20
Control animals:
no
Details on study design:
Recording of symptoms for 7 days after application.

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
7 712 mg/kg bw
Based on:
test mat.
Mortality:
Dead animals after 7 days observation period:
19/20 in 10000 mL/kg bw dose group
16/20 in 8000 mL/kg bw dose group
5/20 in 6400 mL/kg bw dose group
0/20 in 3200 mL/kg bw dose group
Clinical signs:
depression, narcosis.
Gross pathology:
Animals that died: kidney damage

Applicant's summary and conclusion