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The absorption of isopropyl chloride (IPC) was assessed in Sprague-Dawley rats through inhalation exposure in a GLP-compliant study. The blood equilbrium concentrations measured following IPC exposures to 248, 419, and 1007 ppm were 3.7, 4.5, and 9.3 μg/mL, respectively. The biological half-life of IPC in rats was approximately 15 minutes. However, the bioaccumulation potential of IPC could not be determined based on the results of the study.

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Additional information

The absorption of IPC following inhalation exposure was demonstrated in a toxicokinetic study in which male Sprague-Dawley rats underwent a series of acute exposures to 248, 419, or 1007 ppm IPC vapour (Kaegler, 1993). Animals received single head-only exposures of IPC vapour for 6 hours once per week for a total of 7 weeks. Concentrations of IPC increased steadily during exposure and began to decrease immediately thereafter. Equilibrium concentrations (i.e., average peak blood IPC concentrations, at which point the rate of compound entering and exiting the blood is approximately equal) were reached at the last measurement before the end of exposure, and were reported to be 3.7, 4.5, and 9.3 μg/mL in the 248, 419, and 1007 ppm dose groups, respectively. The plasma half-life of IPC in rats was determined to be approximately 15 minutes, demonstrating that IPC is rapidly eliminated from the blood following systemic absorption.

 

No significant dose-related differences in the clearance of IPC from the blood were reported (elimination constants ranged from 0.04 to 0.07 min-1). The distribution, metabolism, and excretion of IPC were not investigated in this study. The bioaccumulation potential of IPC could not be determined based on the results of the study.