Registration Dossier

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Japanese government-sponsored study, stated to have been performed to GLP standard and following OECD test guideline. Linalool, a close chemical analogue of the test item with similar physico-chemical properties, was tested.
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
GLP compliance:
yes
Remarks:
stated to be OECD GLP standard
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Daphnia magna
Test type:
semi-static
Water media type:
freshwater
Total exposure duration:
21 d
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
9.5 mg/L
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
17 mg/L

Results based on the test substance linalool

Conclusions:
This 21-day Daphnia reproduction study with linalool concludes a NOEC of 9.5 mg/l and an EC50 of 17 mg/l.

Description of key information

One key study was identified: this assessed the long-term toxicity of  the chemical analogue linalool to Daphnia magna, in a 21-day reproduction study: a NOEC of 9.5 mg/l was determined.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
9.5 mg/L

Additional information

Linalool is a close chemical analogue of the test item, with similar physico-chemical properties. Results of its testing for long-term toxicity to Daphnia are therefore deemed suitable to assess the equivalent toxicity of the test item. Linalool gave a 21 -day NOEC value of 9.5 mg/l: it is reasonable to assume that dihydromyrcenol would produce a similar response in freshwater invertebrates.