Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 242-362-4 | CAS number: 18479-58-8
The analogue chemical, dimyrcetol, is a skin irritant in rabbits when tested undiluted. The diluted material was not a skin irritant in humans. The analogue chemical, myrcenol, dihydro derivative, is not an irritant when tested in humans at a concentration of 20%. Dihydromyrcenol (undilted) was an eye irritant in rabbits.
In a key study in rabbits, the undiluted analogue chemical, dimyrcetol, applied under semi-occlusive wrap was rated a skin irritant according to Annex V of EEC Directive 78/831 based on a group mean erythema irritation score of 2 or higher for the 24-, 48- and 72-hour observations. Minimal erythema and edema (scores of 0 to 1) persisted to the 168 hour observation. A 50% dilution in diethyl phthalate was not an irritant under the same conditions. All irritant effects noted in the study with 50% test material were resolved by the 168-hour observation point. The results from several supporting skin irritation studies with undiluted dimyrcetol or the analogue chemical, myrcenol, dihydro derivative, indicated similar irritant effects.
In a key study, the analogue chemical, myrcenol, dihydro derivative, showed no irritant effects in a repeated insult patch test when tested at a 20% concentration in human subjects (see Section 7.4.1). In similar supporting studies with dimyrcetol, concentrations ranging from 4 to 10% were not irritating to human skin.
Please refer to Section 13 of this IUCLID file for read-across documentation and rationale for the selection of representative analogue chemicals.
Based on the results of the key study with the analogue chemical, dimyrcetol (group mean erythema irritation score of 2 or greater), dihydromyrcenol would be rated a primary dermal irritant under the EU DSD criteria (EU Directive 67/548/EEC). It would be assigned a Xi:R38 (Irritating to skin) rating. Dihydromyrcenol would be classified for skin irritation under the EU CLP criteria (EU Regulation 1272/2008) as irritating to skin, Category 2. According to the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN-GHS), dihydromyrcenol would be rated as a irritating to skin, Category 3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again