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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Minimal experimental detail and documentation. Information available in a summary document only. Although studies were not conducted according to currently accepted protocols and did not follow GLP procedures, the studies followed acceptable procedures of the time and the results are valid.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Principles of method if other than guideline:
No information available.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of 2,6-dimethyloct-7-en-2-ol and 2,6-dimethyloct-7-en-2-yl formate
EC Number:
915-335-6
Molecular formula:
C11H20O2 C10H20O
IUPAC Name:
Reaction mass of 2,6-dimethyloct-7-en-2-ol and 2,6-dimethyloct-7-en-2-yl formate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No information available.

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No details available.
Doses:
2560, 3200, 4000 or 5000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
No details available.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 100 mg/kg bw
95% CL:
> 3 500 - < 4 800
Mortality:
See Table 1.
Clinical signs:
2560 mg/kg bw: lethargy
3200 mg/kg bw: lethargy, piloerection, blood on nose
4000 mg/kg bw: lethargy, flaccid, ataxia
5000 mg/kg bw: diarrhea

Any other information on results incl. tables

 Table 1: Acute Oral Toxicity in the Rat - Mortality


 













































































Dose Levels (g/kg bwt)



Mortality, total



Day of Death



 



 



0



1



2



3



6



9



11



2.56



1/10



 



 



 



 



 



 



1



3.2



3/10



 



2



 



1



 



 



 



4.0



4/10



 



2



1



 



 



 



 



5.0



8/10



1



5



2



 



 



 



 



 



 



 



 



 



 



 



 



 



 


Table 2: Acute Oral Toxicity in the Rat - Clinical Signs and Necropsy Findings


 















































































































































































































































 



 



Dose Levels (at death/sacrifice)



 



 



2.56



2.56



3.2



3.2



4.0



4.0



5.0



5.0



Necropsy Observations



 



Death



Sacr



Death



Sacr



Death



Sacr



Death



Sacr



 



 



 



 



 



 



 



 



 



 



Normal



 



 



3



 



1



 



 



 



 



Exudate, nose/mouth



 



 



 



 



 



3



 



7



 



Lungs - dark



 



 



 



1



 



 



 



 



 



 



white nodules



 



 



 



 



2



 



 



 



 



dark areas



 



 



2



4



 



6



6



2



Liver - dark



 



1



 



 



1



1



 



4



 



 



mottled



 



3



 



 



2



2



3



 



Kidneys - dark



 



 



 



 



2



 



 



 



 



 



mottled



 



1



 



 



 



 



 



 



Skin - edema



 



 



 



 



 



 



 



 



 



 



hairless



 



 



 



 



 



 



 



 



Intestines - red areas



 



 



 



2



 



3



 



6



 



 



orange areas



 



 



1



 



1



 



1



 



Stomach - red areas



 



 



 



2



3



 



 



 



 



Spleen - large



 



 



2



 



 



2



 



1



 



 



dark



 



 



 



 



 



1



 



 



 

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 value for dimyrcetol in the rat following oral gavage administration was 4100 mg/kg bw. Signs of toxicity described in some animals in this study included lethargy, piloerection, blood on the nose, flaccidity, ataxia, and diarrhea.
Executive summary:

The LD50 value for dimyrcetol in the rat following oral gavage administration was 4100 mg/kg bw. Signs of toxicity described in some animals in this study included lethargy, piloerection, blood on the nose, flaccidity, ataxia, and diarrhea.