Registration Dossier

Administrative data

Endpoint:
biological effects monitoring
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was done with a mixture of substances so possible effects caused by BPA could not be determined.  Only fish were assessed.

Data source

Reference
Reference Type:
publication
Title:
An integrated assessment of estrogenic contamination and biological effects in the aquatic environment of the Netherlands
Author:
Vethaak AD, Lahr J, Schrap SM, Belfroid AC, Rijs GBJ, Gerristen A, de Boer J, Bulder AS, Grinwis GCM, Kuiper RV, Legler J, Murk TAJ, Peijnenburg W, Verhaar HJM, de Voogt P
Year:
2005
Bibliographic source:
Chemosphere 59, 511-524

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
not specified
Type of study / information:
Field study with mixtures

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Significant estrogenic effects were not found in male flounder (Platichthys flesus) in the open sea or in estuaries. Minor to moderate estrogenic effects were observed in bream (Abramis brama) in major inland surface waters. The prevalence of feminizing effects in male fish is largest in small regional surface waters that are strongly influenced by potential hormone-disrupting compounds. High concentrations of plasma vitellogenin and an increased prevalence of ovotestes occurred in wild male bream from a small river receiving large amounts of effluent from a sewage treatment plant.

Applicant's summary and conclusion