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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study discussed in the EU RAR 2003

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1948

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute toxicity by skin penetration (exact site not reported) was determined in 15 rabbits. Rabbits were treated with a 2 g/kg dose of Bisphenol A (administered as a 20 ml/kg dose of a 10% suspension of Bisphenol A in propylene glycol) and the LD50 was estimated.
GLP compliance:
no
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
propylene glycol

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 3 000 mg/kg bw
Remarks on result:
other: 3/15 rabbits died and the authors concluded that the LD50 would be close to 3000 mg/kg
Mortality:
Three of 15 rabbits died after treatment.

Applicant's summary and conclusion

Executive summary:

Acute toxicity by skin penetration (exact site not reported) was determined in 15 rabbits. Rabbits were treated with a 2 g/kg dose of Bisphenol A (administered as a 20 ml/kg dose of a 10% suspension of Bisphenol A in propylene glycol) and the LD50 was estimated. Three of 15 rabbits died after treatment and the estimated LD50 was close to 3000 mg/kg.