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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Biochemical changes in brain in methanol poisoning--an experimental study.
Author:
Rao, K.R. et al.
Year:
1977
Bibliographic source:
Indian J Med Res 65(2): 285-292

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: not specified
Principles of method if other than guideline:
Daily application of a single dose of methanol to monkeys by gavage over a period of 3 days.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methanol
EC Number:
200-659-6
EC Name:
Methanol
Cas Number:
67-56-1
Molecular formula:
CH4O
IUPAC Name:
methanol

Test animals

Species:
monkey
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 30 % solution
- Amount of vehicle (if gavage): no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
3 days
Frequency of treatment:
daily
Doses / concentrations
Dose / conc.:
2 340 mg/kg bw/day (nominal)
Remarks:
Basis: actual ingested
No. of animals per sex per dose:
7 males
Control animals:
not specified

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Mortality:
mortality observed, treatment-related
Description (incidence):
2340 mg/kg bw was the lethal dose for all 7 animals after 3 days.
Body weight and weight changes:
no effects observed
Food consumption and compound intake (if feeding study):
not examined
Food efficiency:
not examined
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not examined
Haematological findings:
not examined
Clinical biochemistry findings:
no effects observed
Urinalysis findings:
no effects observed
Behaviour (functional findings):
not examined
Immunological findings:
no effects observed
Organ weight findings including organ / body weight ratios:
no effects observed
Gross pathological findings:
no effects observed
Neuropathological findings:
no effects observed
Histopathological findings: non-neoplastic:
no effects observed
Histopathological findings: neoplastic:
not examined

Effect levels

Key result
Dose descriptor:
LOAEL
Effect level:
2 340 mg/kg bw/day (actual dose received)
Sex:
male
Basis for effect level:
mortality

Target system / organ toxicity

Key result
Critical effects observed:
no

Any other information on results incl. tables

2340 mg/kg bw was the lethal dose for all 7 animals under test after 3 days.

Applicant's summary and conclusion